Pathophysiology- gasrtic acid stimulation on PUD,GERD,GASTRITIS Essay

Pathophysiology- gasrtic paneling arousal on PUD,GERD,GASTRITIS - Essay ExampleThere are four main phases in the make of gastric acid production and these include basal phase which is constant acid release into the stomach. The cephalic phase involves the preparation for eating and acid secretion is triggered by impulses from higher CNS structures through CN X. superman secretion in the gastric phase is out-of-pocket to distention of the abdomen and the intestinal phase is ruttish by amino acids and intestinal distension (Malfertheiner, 2009).There are several disorders that can occur as a result of hypersacidity which include peptic ulcer disease, gastroesophageal reflux and gastritis. The acid accumulation in these cases is due to a series of aggressive factors such as alcohol, h. pylori and NSAIDs. For example in patients with hyperacid dyspepsia due to Helicobacter pylori there is an increase in gastrin production which stimulates the the parietal cells to produce HCl. Diet ary factors and consumption of alcohol leads to stimulation of gastric mucosa leading to hypersecretion of acid from the parietal cells (Patel & Gyawali, 2012).Genetics have a role to pretend in the exploitation of PUD, gastritis and GERD due to several reasons. Firstly, hyperacid dyspepsia can be a genetic full term whereby an individualist naturally produces an elevated amount of acid therefore making him or her predisposed to exploitation the above mentioned conditions. Other genetic conditions such as hyperpepsinogemenia play a role in the development of peptic ulcer disease. Genetic defects of lower esophageal sphincter function also predispose an individual to GERD. Autoimmune disorders, cancers and allergic reactions increase an individuals chances of developing peptic ulcers or gastritis (Patel & Gyawali,